I GOTTA have a yap about Volume 5 of Homunculus cuz shit has gone to a opposite direction I wasn't expecting.

SPOILERS FOR HOMUNCULUS VOLUME 1 & & 5
From the beginning, Nakoshi meets Mamabu Ito, a 22 year old medical student who's interested in studying humans, and his current fascination is Trepanation - a medical procedure of having a hole drilled into your skull. Ito offered Nakoshi to do the procedure & 10 day experiment for ¥700,000, but he refused. So, his car got towed and Nakoshi had no choice to accept the offer.

Moving forward to Volume 5, Ito tells Nakoshi that the experiment was over, despite the experiment gone for about a week. They had a bit of back & forth with each other until Nakoshi removes the bandage, revealing the already cut-out flap of the skin. He says: "I know for a fact that this hole is real."
Cuz of it, Ito says to Nakoshi: "What kind of delusion... you see when you look at me?"
Nakoshi whips out a sketch of what he sees of himself, then sees a fish inside Ito's body with his right eye close (because he can see 'Homunculi'), and offers a deal to fill the hole in.
Shit goes south in the operating room, he sees more of Ito's homunculi and denies the operation, so Nakoshi orders him to sew his eye shut. The reason why he wants it shut is to explore deeper into his surgeon's homunculi and it all begins after he gets it sewn shut.


I won't go further atm but I'll update more lore when I progress. And add more lore if anyone is interested in Homunculus.